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Faculty Bio

Matthew R. Marcello, Ph.D. is an Associate Professor in the Department of Biology. Prior to joining the faculty at ÌÒñ«ÉçÇø, Dr. Marcello was a National Institutes of Health Institutional Research and Academic Career Development Awards (IRACDA) Postdoctoral Fellow at Rutgers University working in the lab of Dr. Andrew Singson. He received his B.S. in Molecular Biology and Microbiology from the University of Central Florida in 2003. Dr. Marcello earned his Ph.D. in Biochemistry and Molecular Biology from the Johns Hopkins Bloomberg School of Public Health in 2010 under the advisement of Dr. Janice P. Evans.

Awards and Honors

• ÌÒñ«ÉçÇø, 2022, Kenan Award for Teaching Excellence
• ÌÒñ«ÉçÇø, 2015, Kenan Award for Faculty Development
• National Academies, 2011, Education Fellow in the Life Sciences
• American Society of Andrology, 2011, Outstanding Trainee Investigator Award

Licensures and Certificates

• Johns Hopkins Bloomberg School of Public Health, Environmental and Occupational Health Certificate The program is intended for working professionals who are currently in industrial hygiene and/or occupational safety and health practice. This certificate can stand alone as professional development, serve as an entry-point for admission to the MSOEH program, or prepare you for the Certification in Industrial Hygiene (CIH) exam.

PhD, Johns Hopkins University, Baltimore, Maryland, 2010
Biochemistry and Molecular Biology

BS, University of Central Florida, Orlando, Florida, 2003
Molecular Biology and Microbiology

Research Interest

Dr. Marcello leads a laboratory group of undergraduate and masters-level researchers at that is focused on understanding the molecular basis of sperm-egg interactions using C. elegans as a model organism. Former Marcello Lab members have advanced to graduate programs, medical school, dentistry school, optometry school, veterinary school, and various biomedical careers. Dr. Marcello also conducts biology education research to determine effective teaching strategies.

Past Courses

BIO 101: General Biology I
BIO 102: General Biology II
BIO 103: The Biology of Sexual Rprdctn
BIO 231: Genetics
BIO 321: Developmental Biology
BIO 335: Molecular & Cellular Biology
BIO 345: Introduction to Toxicology
BIO 375: Advanced Cell Biology
BIO 395: Independent Study in Biology
BIO 396: Guided Study in Biology
BIO 399: Fundmntls in Rprdctve Biology
BIO 399: Genomics
BIO 480: Research in Biology
BIO 481: Research in Biology II
BIO 491: Internship in Biology
BIO 493: Major Field Test in Biology
BMB 710: Research I
BMB 711: Research II
UNV 101: First-Year Smnr Unvrsty Cmmnty

Publications

The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans
Krauchunas, A. R., Marcello, M. R., Looper, A., Mei, X., Putiri, E., Singaravelu, G., Ahmed, I. I. & Singson, A. (2023). Current Biology. Vol 33 (Issue 14)

RNA sequencing dataset characterizing transcriptomic responses to dietary changes in Caenorhabditis elegans.
Schumacker, S. T., Chidester, C. A., Enke, R. A. & Marcello, M. R. (2019). Data in Brief. Vol 25 (Issue 104006)

The Caenorhabditis elegans Sperm Membrane Protein Interactome
Marcello, M. R., Druzhinina, M. & Singson, A. (2018). Biology of Reproduction.

The Molecular Complexity of Fertilization: Introducing the Concept of a Fertilization Synapse
Krauchunas, A. R., Marcello, M. R. & Singson, A. (2016). Molecular Reproduction and Development.

Fertilization
Marcello, M. R., Singaravelu, G. & Singson, A. (2013). Adv Exp Med Biol.

Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm
Marcello, M. R., Jia, W., Leary, J. A., Moore, K. L. & Evans, J. P. (2011). Journal of Biological Chemistry. Vol 15 (Issue 286)

Germline Determination: Don’t Mind the P Granules
Marcello, M. R. & Singson, A. (2011). Curr Biol..

Multivariate analysis of male reproductive function in Inpp5b-/- mice reveals heterogeneity in defects in fertility, sperm-egg membrane interaction, and proteolytic cleavage of sperm ADAMs
Marcello, M. R. & Evans, J. P. (2010). Mol Hum Reprod..

Fertilization and the oocyte-to-embryo transition in C. elegans
Marcello, M. R. & Singson, A. (2010). BMB Rep..

Professional Memberships

• Society for the Study of Reproduction
• Genetics Society of America
• American Society of Andrology

Public Service

• Brooklyn Book Bodega